Aim: To investigate the influence of XPC, PMAIP1/Noxa, and TLR4 genetic variants on the development of bleomycin-induced lung injury (BILI) in south Indian patients with Hodgkin lymphoma.
Methods: Hodgkin lymphoma patients receiving adriamycin, bleomycin, vinblastine, and dacarbazine regimen were recruited for the study and BILI was diagnosed based on symptoms and/or radiological signs. DNA samples were genotyped using real-time PCR.
Results: A total of 78 patients were recruited in the study and BILI was observed in 17 (21.8%) patients. Polymorphisms in XPC, PMAIP1/Noxa and TLR4 genes were not associated with the development of BILI.
Conclusion: The selected genetic polymorphisms do not predict the risk of BILI in the south Indian population.